• Login
    • University Home
    • Library Home
    • Lib Catalogue
    • Advance Search
    View Item 
    •   IR@KDU Home
    • FACULTY STAFF PUBLICATIONS
    • Journal Articles
    • View Item
    •   IR@KDU Home
    • FACULTY STAFF PUBLICATIONS
    • Journal Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Evaluation of In vitro Anti-Inflammatory and Antibacterial Properties of Tuberous Roots of Mirabilis jalapa L. Found in Sri Lanka

    Thumbnail
    View/Open
    Anti bacterial_inflammatory_MJ_Full.pdf (1.440Mb)
    Date
    2023-08-14
    Author
    Ranaweera, CB
    Fernando, D. T. K.
    Peiris, D. S. H. S.
    Chandana, AK
    Senadeera, SPNN
    Metadata
    Show full item record
    Abstract
    Aims: This study aims to evaluate the in vitro anti-inflammatory and antibacterial potential of aqueous and various organic solvent (methanol, dichloromethane, and hexane) extracts of Mirabilis jalapa L. tuberous roots. Methods: Heat-induced egg albumin denaturation inhibition assay and hypotonicity-induced human red blood cell (HRBC) membrane stabilization methods were used to evaluate the anti-inflammatory activity in vitro. Both disc diffusion and well diffusion methods were utilized to evaluate the antibacterial potential in vitro, using three common wound pathogens. Namely, Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), and Staphylococcus aureus (ATCC 25923). Results: In the heat-induced egg albumin denaturation inhibition assay, the methanolic extract of M. jalapa exhibited the highest potency (IC50 = 137.9 µg/ml) of anti-inflammatory activity while in the HRBC membrane stabilization method, the aqueous extract of M. jalapa exhibited the highest potency (IC50 = 197.4 µg/ml) of anti-inflammatory activity. There was no significant antibacterial activity shown by all four extracts. However, some inhibitory zones were observed in the well diffusion method against S. aureus. The highest inhibitory zone of 15.33 ± 0.33 mm was expressed by the dichloromethane extract, with a concentration of 400 mg/mL against S. aureus, followed by the hexane extract with an inhibitory zone of 14.00 ± 2.08 mm at the same concentration. The dichloromethane extract showed an inhibitory zone of 11.00 ± 0.58 mm at a 200 mg/mL concentration. Conclusion: This study demonstrates that the tuberous roots of M. jalapa have significant anti inflammatory properties but no significant antibacterial properties against the selected pathog
    URI
    http://ir.kdu.ac.lk/handle/345/6676
    Collections
    • Journal Articles [85]

    Library copyright © 2017  General Sir John Kotelawala Defence University, Sri Lanka
    Contact Us | Send Feedback
     

     

    Browse

    All of IR@KDUCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsFacultyDocument TypeThis CollectionBy Issue DateAuthorsTitlesSubjectsFacultyDocument Type

    My Account

    LoginRegister

    Context

    Edit this item

    Library copyright © 2017  General Sir John Kotelawala Defence University, Sri Lanka
    Contact Us | Send Feedback