Can Clomiphene Citrate Improve the Quality of Seminal Fluid Parameters in Idipathic Oligoasthenoteratozoospermic Males

Abstract

Introduction: Male infertility is a rising problem worldwide. Idiopathic male infertility is responsible for 31% of all male infertility. Among them 44% is due to Idiopathic Oligo Astheno Terotozoospermia (iOAT) syndrome. The role of medical treatment in managing iOAT syndrome is controversial . But there are accumulating evidence of the efficacy of Clomiphene citrate on treating iOAT syndrome. Objective: To determine the efficacy of Clomiphene Citrate therapy in improving seminal fluid parameters of a group of male patients with iOAT syndrome. Study type: a comparison study was done using retrspective data. Method: This study was conducted in the Reproductive biology laboratory of the Faculty of Medicine, Galle. Medical records of 52 patients presented with iAOT syndrome, treated with clomiphene citrate were screened using the exclusion and inclusion criteria. The pre-tratment and post-treatment seminal fluid analysis of the patients were compared using the paired t- teast. All the patients were given clomiphene citrate 50mg per day in divided doses for minimum of 3 months. Post-treatment seminal fluid analysis were done at the end of the 4th month of commencing the treatments. Results: Sperm concentration, sperm total count, normal morphology, motility and viability are improved significantly (p<0.001). The improvement of the volume is not significant (p> 0.001) Conclusion: Clomiphene citrate improves the sperm concentration, total count, normal morphology, motility and viability in a group of selected male patients with iOAT syndrome but the volume.