| dc.description.abstract | Ischemic heart disease (IHD) remains a leading cause of morbidity and mortality globally. In recent
years research has increasingly focused on the interplay between the white blood cells and the
development and progression of IHD. Neutrophils, lymphocytes, and Monocytes play an important
role in the immune system and were found to have dual roles in both protective mechanisms and
harmful effects. Neutrophils are traditionally viewed as first responders to tissue injury. Their rapid
infiltration aids in the clearance of cellular debris and pathogens, while the release of reactive
oxygen species and inflammatory mediators can exacerbate tissue damage. Additionally,
neutrophils participate in intercommunication with endothelial cells and platelets, influencing the progression of atherosclerosis and thrombosis. Lymphocytes, a key player in adaptive immune
response, similarly exhibit a dual role in IHD. Their involvement extends beyond immune
surveillance. Monocytes contribute to phagocytosis and tissue repair while some of their actions
cause atherosclerotic plaque instability. This review provides an overview of IHD, covering its
prevalence, pathogenesis, risk factors, clinical manifestations, diagnosis, and the involvement of
white blood cells, including neutrophils, lymphocytes, and monocytes, in the disease process. | en_US |
