• Login
    • University Home
    • Library Home
    • Lib Catalogue
    • Advance Search
    View Item 
    •   IR@KDU Home
    • INTERNATIONAL RESEARCH CONFERENCE ARTICLES (KDU IRC)
    • 2021 IRC Abstracts
    • Allied Health Sciences
    • View Item
    •   IR@KDU Home
    • INTERNATIONAL RESEARCH CONFERENCE ARTICLES (KDU IRC)
    • 2021 IRC Abstracts
    • Allied Health Sciences
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Classification of Patients with Epilepsy and Healthy Subjects Using Structural MRI; A Tensor-Based Morphometry Study

    Thumbnail
    View/Open
    Allied-Health-Sciences E - Copy-22.pdf (511.7Kb)
    Date
    2021
    Author
    Piyumali, WADH
    Jayasinghe, GDYB
    Egodage, S
    Ediri Arachchi, WM
    Metadata
    Show full item record
    Abstract
    Computational neuroanatomy using magnetic resonance imaging (MRI) has been used extensively in studies of epilepsy to detect morphological abnormalities (Grey matter and White matter volumes) of the brain. However, it is unclear how epilepsy affects gross volume changes in the human brain. The aim of this study was to explore gross volume changes in the epileptic brain and to test the potential of gross volume changes to develop a neuroimaging tool for the objective diagnosis of epilepsy. We recruited 47 healthy controls and 48 epilepsy patients and T1 weighted structural MR brain scans were acquired using a 1.5 Tesla scanner at Army Hospital, Narahenpita, Sri Lanka. We applied the tensor-based morphometry (TBM) method (a variation of DBM) to generate voxel-level Jacobian determinant images using the Computational Anatomy Toolbox (CAT). Furthermore, group-level univariate analysis was conducted using two sample t-tests including age and gender as covariates. In addition, Multivariate pattern analysis (MVPA) was performed using univariate findings to distinguish patients with epilepsy healthy controls. We found widespread gross volume reductions in anatomical regions in frontal, temporal, and occipital regions and subcortical structures such as hippocampus and anterior cingulum. The multivariate pattern analysis (MVPA) results showed that gross brain volume changes can be effectively used to distinguish patients with epilepsy healthy controls (TBM: accuracy =70.83%). In summary, our study concludes that gross volume changes detected in epileptic brain should be considered when developing a neuroimaging tool for objective diagnosis of epilepsy.
    URI
    http://ir.kdu.ac.lk/handle/345/4483
    Collections
    • Allied Health Sciences [68]

    Library copyright © 2017  General Sir John Kotelawala Defence University, Sri Lanka
    Contact Us | Send Feedback
     

     

    Browse

    All of IR@KDUCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsFacultyDocument TypeThis CollectionBy Issue DateAuthorsTitlesSubjectsFacultyDocument Type

    My Account

    LoginRegister

    Library copyright © 2017  General Sir John Kotelawala Defence University, Sri Lanka
    Contact Us | Send Feedback