| dc.description.abstract | Abstract:-Urolithiasis or the formation of
urinary stones is a major non communicable
disease that affects the urinary system. Among
the different types of renal stones CaC2O4 are the
overwhelming. Antiurolithiatic activity is the
inhibition of formation of urinary stones. There
is a high demand for herbal medicines to treat
urolithiasis due to unavailability of a successful
drug devoid of complications. Passiflora foetida
(Udahalu) & Stachytarpheta indica (Balunakuta)
plants are used in the treatment of kidney stones
in traditional medicine. This study was aimed to
investigate in-vitro antiurolithiatic activity of
these plants on experimentally prepared CaC2O4
crystals. The crude plant extracts were prepared
by boiling the dried plant material in water
followed by evaporation of the solvents via
rotary evaporation. A concentration series of
aqueous extract of the plants were prepared
with negative and positive (cystone tablets)
controls. Antiurolithiatic activity was evaluated
using the UV/visible spectrophotometry by
measuring optical density of each samples
having different concentrations of the plant
extracts at 620 nm. The mean absorbance of
P.foetida extract at 0.125 mg/mL, 0.25 mg/mL,
0.5 mg/mL, 1 mg/mL, 2 mg/mL, 4 mg/mL
concentrations were 0.045, 0.062, 0.105, 0.216,
0.1393, 0.623 respectively. The mean
absorbance of S. indica extract at 0.125 mg/mL,
0.25 mg/mL, 0.5 mg/mL, 1 mg/mL, 2 mg/mL, 4
mg/mL concentrations were 0.180, 0.260,
0.201, 0.959, 0.862, 0.492 respectively. There is
a concentration dependent increase in the mean
absorbance for the samples. The results reveal
that both extracts exhibit antiurolithiatic
activity and the highest activity is exhibited by S.
indica. | en_US |
