| dc.description.abstract | Aplastic anaemia (AA) is a rare but potentially fatal disorder of the bone
marrow characterised by severe pancytopenia and hypocellular marrow.
Viral infections are recognised secondary causes of AA. Parvovirus B19
is more commonly associated with transient aplastic crisis or pure red cell
aplasia rather than true aplastic anaemia. We report a case of severe aplastic
anaemia in a previously healthy 29-year-old male, attributed to acute
Parvovirus B19 infection. He presented with symptoms of anaemia, fever,
and painful oral ulcers and was found to have severe pancytopenia with
reticulocytopenia and hypocellular bone marrow. Extensive evaluation
excluded autoimmune, malignant, and other infectious causes. Parvovirus
B19 serology confirmed recent infection. Despite supportive care and
immunosuppressive therapy with anti-thymocyte globulin (ATG), the
patient developed refractory neutropenic sepsis and succumbed to
complications. This case highlights parvovirus B19 as a rare but important
cause of acquired aplastic anaemia, as well as the challenges clinicians
face in managing AA in resource-limited settings. | en_US |
