| dc.description.abstract | Extracellular vesicles (EVs) are nano-sized, membrane-bound particles
secreted by cells under physiological conditions and are involved in
multiple functions, especially cell signaling. They are found in body fluids
including blood, saliva, semen, bile, cerebrospinal fluid, amniotic fluid,
breast milk, and urine. The molecular cargoes encapsulated by the EVs
provide information about the cells of their origin. More recent deve
lopments in liquid biopsies have enabled uncovering the potential
diagnostic uses of these vesicles offering an alternative to traditional
biopsy enquiries in pathology. In the field of cancer, cancer-associated
exosomes have been explored for early diagnosis with biomarkers to
determine prognosis and therapy responses. This review filters recent
advancements in EV biology and focuses on EV biogenesis and how EVs
play a pivotal role in mediating intercellular communication in cancer. We
draw attention to EV molecular profile with cargo heterogeneity which
warrants scientists to develop precision therapeutic strategies to enhance
treatment efficacy. Integrating EV analysis into clinical practice holds
significant potential to revolutionize cancer diagnostics and therapeutic
approaches, paving the way for more effective patient-centered healthcare
solutions. | en_US |
