| dc.description.abstract | FLT3-ligand (FL) in human plasma stimulates the proliferation of white blood cells (WBC)
and suppresses lymphomas. This study was aimed at detecting FL levels in non-Hodgkin
lymphoma (NHL) patients and healthy individuals to find the correlations between FL and
absolute WBC counts. Ethical clearance was obtained from the ethical review committee
of KDU. EDTA plasma samples (n = 12) of confirmed NHLs (before chemotherapy) and
healthy (n = 7) were analyzed by ELISA to quantify FL. NHLs were divided into 03
subpopulations; FL < 10 pg/ml (subgroup I, n = 5), 10 - 100 pg/ml (subgroup II, n = 4), and >
100 pg/ml (subgroup III, n = 3). Absolute-Lymphocyte-Count (ALC), Absolute-Neutrophil Count (ANC), Absolute-Eosinophil-Count (AEC), Immature-Granulocytes (IMG), Neutrophils/Lymphocytes (NLR), and Lymphocytes/Monocytes (LMR) were compared statistically by SPSS-26: Mann-Whitney analysis among sub-groups. ANC, NLR, and IMG were
significantly higher (p < 0.05) and AEC was lower (p < 0.05) in subgroup I than in II. IMG
was significantly higher (p < 0.05) and AEC was lower (p < 0.05) in subgroup I than in III.
AEC was significantly higher (p = 0.05) in subgroup II than in III. The average FL was
41.5 pg/ml in the healthy group. ALC, AEC, and LMR were significantly higher(p < 0.01)
and total WBC, ANC, IMG, and NLR were lower (p < 0.01) in the healthy group than in
NHL sub-group I. IMG, LMR, and NLR were significantly higher (p < 0.05) in the healthy
group than in sub-group III. IMG was significantly higher (p < 0.01) in the healthy group
than in sub-group II. It was shown that NHLs with lower FL had more deviated WBC
counts, NLR, and LMR than other NHLs and healthy individuals. This preliminary study
is currently being expanded to monitor the patients to detect the survival rate according
to the initial FL level in NHL patients. | |
