| dc.description.abstract | Chronic Kidney Disease (CKD) is a health issue a ecting nearly 13.4% of the global population
and also a major burden on the health sector of Sri Lanka. The investigation of the
estimated Glomerular Filtration Rates (eGFR) plays a vital role in disease diagnosis, CKD
stage determination and patient management. Various equations have been developed
for GFR estimation, but the CKD stage of a patient may vary based on the equation
used. Therefore, this study was focused on comparing and identifying variations among
eGFR values calculated using six serum creatinine based equations. A cross sectional
and analytical study was conducted using 205 CKD patients attending the Nephrology
clinic, Teaching Hospital, Kurunegala. An additional blood volume was collected for
serum creatinine testing, during routine blood collection and analysis were performed at
a registered laboratory in Colombo. The eGFR was calculated for every patient using ve
equations: 4 - variable - MDRD, Cockcroft Gault (CG), CKD - EPI, Full Age Spectrum
(FAS) and Mayo Clinic Quadratic (MCQ ). Berlin Initiative Study-1 (BIS-1) equation was
additionally used for patients of age 70 years. Accordingly, the equations; CKD - EPI,
FAS and MCQ showed statistically signi cant mean di erences with the routinely used
MDRD equation while it was not so between MDRD and CG equations. In patients of
age 70, BIS - 1, CKD - EPI and CG equations showed signi cant mean di erences
with the MDRD equation, but it was not so in FAS and MCQ equations. Repeated
measures ANOVA revealed that the GFR values of the same patient varied signi cantly (p
< 0.001) among the ve equations considered. This study provides evidence for deviations
among equations in eGFR estimation and CKD stage determination. Therefore, it can be
concluded that there is a necessity of modifying and adapting eGFR equations to suit our
population. | en_US |
