| dc.description.abstract | Psidium sp leaves have traditionally been used to manipulate several diseases over the
last decades. Exploring the potential bioactive metabolites from fruit plant leaves has
widely increased. There are many approaches carried out to discover the bioactive
compounds present in fruit plants and their parts. In this study, three different Psidium
species, including Psidium guineanse, Psidium guajava, and Psidium cinereum leaves
were subjected to ethanol extraction and the phytochemical analysis by total
polyphenolic content (TPC) and total flavonoid content (TFC) assays was evaluated.
Anti-α-amylase, and radical scavenging activity by oxygen radical absorbance capacity
(ORAC), ferric reducing antioxidant power (FRAP), and DPPH assays were performed
to screen the bioactivities. Among the extracts, P. guajava showed the highest TFC
(7.33±1.92 mg quercetin equivalent/g), and P. guineanse showed the highest TPC
(240.75±77.58 mg GAE/g of extract) compared to other extracts. In addition, P.
guajava leaf ethanol extract showed the highest DPPH (93.05±0.85 mg Trolox
equivalent/g of extract), ORAC (1.04±0.05 μg Trolox Equivalent/g of extract), and
FRAP (256.85±48.15 mg Trolox equivalent/g of extract) radical scavenging activities,
respectively. α-amylase inhibitory activity of P. guajava has resulted in the highest
(IC50 of 0.975 mg/mL) compared to other extracts followed by the highest yield
(14.33%). Collectively, the ethanol leaf extracts of P. guajava were determined with
high phytochemicals such as polyphenolics, radical scavenging, and anti-α-amylase
activity compared to the other extracts. However, further research to evaluate in vitro
toxicity is considered. | en_US |
