| dc.description.abstract | Accurate risk assessment of cardiovascular disease (CVD) plays a pivotal role in
preventing coronary heart disease, stroke, etc. which could be life threatening.
This study aimed at investigating the correlation of Atherogenic Index of Plasma
(AIP) and Atherogenic Coefficient (AC) with Atherosclerotic Cardiovascular
Disease (ASCVD) Risk Calculator. Patients (153) suffering from diabetes mellitus,
anaemia, hyperthyroidism, etc. satisfying the two inclusion criteria; age group of
40-79 years and having undergone serum lipid profile testing for cardiovascular
risk assessment while having no clinical history of myocardial infarction or chest
pain were selected from Medical Clinic of University Hospital KDU, Sri Lanka
during 1 month period. Socio-demographic data were collected via interviewerbased
questionnaires. Drug-history, blood pressure values were extracted from
patients’ histories and lipid parameters from lab reports. Statistical analysis was
carried out using SPSS version 20. Results revealed that elevated systolic blood
pressure and hyperglycaemia were predominant risk factors in this population
with prevalence of 79.3% and 71.1% respectively. Moreover, elevated systolic
blood pressure also correlated with 10-year ASCVD risk (r=0.386). 10-year
ASCVD risk did not correlate with either AIP or AC, whereas AIP correlated with
Triglycerides (TG) (r=0.829) and High Density Lipoprotein (HDL) Cholesterol
(r=-0.682). Thus, AIP and AC showed more potency in CVD risk estimation than
using traditional lipid parameters alone, especially when lipid parameters were
within normal range, which would have otherwise masked or underestimated the
CVD risk. Hence, these indices can be used as biomarkers of CVD risk assessment
and should be incorporated into routine clinical investigations. | en_US |
