| dc.description.abstract | Graphene-based nanocomposites have been recognized as effective drug delivery
systems due to their unique properties such as two-dimensional structure,
biocompatibility, easy surface modification, and high efficacy in drug loading and
releasing. Vanillin, gallic acid, and quercetin are natural bioactive compounds that
exhibit a variety of pharmacological properties. The objective of the present study
is to evaluate the loading capacity and releasing efficiency of vanillin, gallic acid, and
quercetin in PEGylated nano-Graphene Oxide (PEG-nGO). Nano-graphene oxide was
synthesized using a modified Hummer’s method followed by ultrasonication and
PEGylation. Then vanillin, gallic acid and quercetin were separately loaded into PEGnGO
in different ratios (1:1, 1:10, 1:100, 1:1000 of PEG-nGO: bioactive compound).
The prepared nanocomposites were studied for loading efficiency, loading capacity,
and releasing efficiency. Among different nanocomposites, the 1:1 ratio of
quercetin-loaded PEG-nGO showed the highest loading capacity of 37.79±0.016%.
Vanillin (3.80±0.005%) and gallic acid (2.68±0.012%) exhibited comparatively
lower loading capacity in the nanocomposites with a 1:10 ratio. Compared to the
other two bioactive compounds (vanillin: 39.54±0.005% and gallic acid:
27.53±0.012%) the loading efficiency was also considerably high in quercetin
(60.74±0.016%) loaded nanocomposite. Further, quercetin showed the highest
releasing ability with an initial rapid release within the first 06 hours
(65.89±0.001%) followed by gradual release within the next 72 hours
(95.22±0.001%), while vanillin (67.25±0.001%) and gallic acid (46.79±0.04%)
exhibited a comparatively less release within 72hours. The results of the present
study revealed that PEG-nGO loaded with quercetin could be used as an efficient
nanocomposite for the development of smart pharmaceutical products. | en_US |
