| dc.description.abstract | Fatigue is the main obstacle to maintaining stamina. It deteriorates the capacity for
the physical workout of an athlete and the quality of life of a normal person. Fatigue
occurs due to the accumulation of reactive free radicles and increased energy
consumption as ATP and glycogen. Athletes use several anti-fatigue substances like
Caffeine, creatinine etc. to enhance endurance. The drawback of these substances is
the adverse effects on health. Hence, it is high time to explore safe herbal anti-fatigue
formula to improve endurance. The SM herbal formula is a modified authentic
herbal recipe primarily used as an anti-fatigue formula mentioned in ancient
Ayurveda authentic books. This study focused on evaluating the anti-fatigue activity
of the SM herbal preparation in rats using the Acute Weight-Loaded Forced
Swimming Test (AWLFST). Twenty-four healthy albino Wistar rats were randomly
divided into four groups. 5ml/Kg of distilled water, Caffeine (20mg/Kg), 200mg/Kg
of aqueous extracts of the drug, and 200mg/Kg of alcohol extracts of the drug were
administered orally for the groups 1, 2 ,3 and 4 accordingly for 14 days. The rats
were taken for the AWLFST on the 14th day. Exhaustion time was determined and
the experiment is repeated every alternate day for two weeks. Data were analyzed
statistically using graph pad prism software. All the groups showed significant
positive results compared to the negative control. The adjusted p values of the mean
immobility period of group 2, 3, and 4 are 0.0020, 0.0002, and 0.0058 respectively.
Further, rats who received aqueous extract of the drug (group 3) exhibited highly
significant results (P> 0.001). Results indicate that SM preparation can improve
endurance against exercise-induced fatigue. | en_US |
