| dc.description.abstract | Abstract: Curcuma zedoaria is a perennial
herb which belongs to the family
Zingiberaceae. In traditional medicine, the
rhizome of Curcuma zedoaria is used to treat
various diseases including inflammatory
conditions. The objectives of the study were
to formulate a stable anti-inflammatory
cream by incorporating aqueous extract of
Curcuma zedoaria rhizome (ARE) and to
investigate its phytochemicals. ARE was
screened for phytochemicals. Fourteen
different trial base formulations were
developed by drop-wise addition of aqueous
phase to the oil phase with continuous
stirring at 600C (fusion method). The
formulations were subjected to
characterization tests and stability tests (real
time and accelerated) for 90 days. Among
them, the best two base formulations, which
were stable for the tested period of 90 days,
were selected. Creams with 0.75%, 1% and
1.5% (w /w) of ARE were prepared using the
selected two base formulations and
characterization and stability studies were
conducted. Creams with 0.75% and 1%
(w/w) ARE were stable for 90 days at both
real and accelerated conditions. According to
the characterization, all creams were
identified as oil in water emulsions with pH
of 6. The parent base texture was not
changed after incorporating the extract.
Flavonoids, tannins, alkaloids, saponins,
terpenoids, carbohydrates and gums were
present in ARE. It is concluded that using newly
formulated bases, stable anti-inflammatory
cream can be formulated by incorporating ARE
of Curcuma zedoaria, a plant which is well
known to have anti-inflammatory activity in
traditional medicine. It is recommended to
establish quality control standards for the novel
formulation for future studies. | en_US |
