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Evaluation of Anti-inflammatory and Antibacterial activities of the extracts of leaves, roots and combination of leaves and roots of plant Magnolia figo.

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dc.contributor.author Abeykoon, AMAU
dc.contributor.author De Silva, GMCP
dc.contributor.author Karunathilake, KTSS
dc.contributor.author Silva, ARN
dc.contributor.author Bandara, AWMKK
dc.contributor.author Pathirana, RN
dc.date.accessioned 2020-12-31T19:45:01Z
dc.date.available 2020-12-31T19:45:01Z
dc.date.issued 2020
dc.identifier.uri http://ir.kdu.ac.lk/handle/345/2912
dc.description.abstract Abstract:-Discovery of novel drugs from medicinal plants is getting popular owing to lesser side effects and to overcome antimicrobial resistance. The methanolic extracts of both leaves and roots of Magnolia figo plant by cold maceration were subjected to the evaluation of anti-inflammatory and antibacterial activity. In vitro antiinflammatory property was determined using heat-induced protein (egg albumin) denaturation test compared to diclofenac sodium (positive control). Concentration series of the extracts were analyzed to calculate the percentage inhibition (IC50) of heat-induced protein denaturation. Antibacterial activity of the methanolic extract was determined against Escherichia coli (ATCC® 25922TM) and Staphylococcus aureus (ATCC® 25923TM) using the cylinder plate method using gentamycin as the positive control. The size of inhibitory zone was compared with the positive control to determine the antibacterial activity. Lower IC 50 value (1.819 (µg/mL)) was shown in the combination extract of M. figo plant compared to the reference drug (4.337 (µg/mL)). It reflects the synergistic effect of the plant parts. The leaves and roots combination extract exhibited dose-dependent behavior of antiinflammatory activity and highest antibacterial activity against E. coli (zone diameter – 15 mm). However, none of the extracts exhibited antibacterial activity against S. aureus. Phytochemical investigations of extracts indicated the presence of alkaloids, flavonoids, phenols, tannins, saponins, terpenoids, glycosides and steroids. Significant results elicited by the combination of plant parts confirm that M. figo is a medicinal plant which can be used to develop novel anti-inflammatory agents. en_US
dc.language.iso en en_US
dc.subject Antibacterial activity, Antiinflammatory activity, Magnolia figo, en_US
dc.title Evaluation of Anti-inflammatory and Antibacterial activities of the extracts of leaves, roots and combination of leaves and roots of plant Magnolia figo. en_US
dc.type Article Full Text en_US
dc.identifier.journal 13th International Research Conference General Sir John Kotelawala Defence University en_US
dc.identifier.pgnos 105-110 en_US


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