| dc.description.abstract | Among variety of medical imaging modalities,
nuclear imaging method is a safe, has less side
effects and is a painless technique to image the
body and diagnose diseases. The objective of this
study was to determine the amount of radionuclide
activity in bladder during bone scan and to
estimate the percentage of radionuclide activity
in the bladder compared to injected dose. Results
of the study were used to find out the correlation
between Body Mass Index (BMI) and amount of
activity in bladder and the correlation between
gender and radionuclide activity in bladder in the
bone scan. A cross-sectional study was conducted
among patients referred to Tc99m Methylene
Di-Phosphanate (MDP) whole-body bone scans
to estimate the radionuclide activity in bladder
by using dual head Single Positron Emission
Computed Tomography (SPECT) machine. One
hundred (100) patients were selected for study.
After two hours of injection of Tc99mMDP, scan
was performed. The total counts were taken
by drawing region of interest (ROI) around the
bladder in each image. Conjugate view method
was used to convert count into activity. The mean
value of bladder activity fraction was 0.075%
(ranged from 0.39% to 0.012%) with Standard
Deviation (SD) of 0.076. According to the Kruskal
Wallis test, there was no correlation between BMI
and bladder activity with P = 0.923 (P > 0.05) and
according to the Mann-Whitney test, there was a
correlation between gender and bladder activity
with P = 0.002 (P < 0.05). Bladder receives very
less amount than 0.5% of activity as a non-imaging
organ during bone scan and the estimation of
bladder activity is worth because the patients can
be encouraged to be well-hydrated after injection
to eliminate radiopharmaceuticals from body. | en_US |
