| dc.description.abstract | This randomized prospective cohort clinical study was done to evaluate the effect of cold water extract of new herbal formulation consisting of Allium sativum (Bulb) Piper nigrum (Nuts) Murrayakoenigii (Leaves) in managing hyperlipidaemic conditions of patients in comparison to the effect of dietary management. After 14 days treatment, patients of the group A, which received cold water extract showed 19.3% decrease in serum total cholesterol level in comparison to the level of same parameter before the treatment (p<0.05) whereas it showed statistically significant decrease in serum triglyceride (29%), LDL (26.5%) and TC:HDL ratio (32.3%) but the patients of group B, which received dietary management did not show significant reduction in the serum levels of total cholesterol, triglyceride, LDL and TC:HDL ratio compared to those of before treatment of same group. The patients of group A showed significant decrease in serum concentrations of total cholesterol (16.5%), triglyceride (29.3%), LDL (5.3%) and TC/HDL ratio (21.4%) while showing considerable increase in HDL level in comparison to the serum concentrations of same lipid parameters of Group B after 14 days treatment. Considering the overall results of present study and comparing with the results of previous studies, it is evident that the short term administration of cold water extract of new herbal formulation has shown significant effect in decreasing the elevated serum lipid levels (except to the HDL levels) than the effect of given dietary management alone in hyperlipidaemic patients without causing clinically evident adverse effects. | en_US |
