Browsing by Author "Halahakoon, HMAJ"
Now showing items 1-12 of 12
-
The Assessment of the Capping Tendency of the Tablet during The Pharmaceutical Tabletting Using Finite Element Analysis in Computational Modelling Tools
Halahakoon, HMAJ (2022)The pharmaceutical powder compression cycle can be subdivided into several stages, which are associated with numerous complex mechanisms. The rearrangement and densification of particles, inter-particle interaction and ... -
Developing a Sulfur-based Antifungal Solution for Dermatophytosis and Assessment of its Antifungal Activity in-vitro against Microsporum canis – A Pilot Study from Sri Lanka
Dharmasiri, HWCS; Wijayarathna, DMPI; Eranga, PAU; Jayawardena, MN; Halahakoon, HMAJ; Jayaweera, GU (2023-09)Dermatophystosis is a skin condition affecting the cosmetic appearance and the quality of life of people. This is caused by many species of dermatophytes, among them is Microsporum canis, a fungus in canine and feline ... -
Enhancing the Solubility of Atorvastatin Calcium: A Comparative Study of Solid Dispersions with β-Cyclodextrin, Chitosan, and PEG-4000
Vithana, SC; Sandaru, WH; Halahakoon, HMAJ; Nelumdeniya, NRM (2020-09-26) -
Exploring Phytochemicals in Glycyrrhiza Glabra L. Root as Potential Therapeutics for Gastroesophageal Reflux Disease: A Molecular Docking and Dynamics Study
Dias, MGLS; Kalhari, RDVK; Nelumdeniya, NRM; Halahakoon, HMAJ (2024-09-26) -
Formulation of Anti-inflammatory Topical Application using Acronychia pedunculata, Thespesia populnea and Madhuca longifolia Extracts
Perera, SDS; Kamalanathan, S; Halahakoon, HMAJ; Sabalingam, S (2024-09-26) -
Formulation of Herbal Anti-Inflammatory Cream Combining Barringtonia racemosa, Curcuma longa and Phyllanthus amarus Extracts
Sumanarathne, EBD; Sameera, KAP; Athukorala, AK; Nelumdeniya, NRM; Halahakoon, HMAJ (2022)Phyllanthus amarus, Barringtonia racemosa and Curcuma longa are well-known herbal plants with anti-inflammatory activity that are used in traditional medicine. An attempt was made first to determine the in-vitro ... -
In Silico Study of the Computationally Designed Novel Vinca Alkaloid Derivatives VADRPA01 and VADRPH01 Effects on Calmodulin and Calmodulin Dependent Ca2+ Transport ATPase
Halahakoon, HMAJ (2023-09)Vinblastine was the first Vinca Alkaloid (VA) with antiproliferative properties discovered in plant C. roseus. The ability of VA drugs to bind with the Calmodulin (CaM) and Calmodulin-dependent Ca 2+ transport ATPase ... -
In-Vitro Evaluation of Gastroprotective Activity and Phytochemical Screening of the Aqueous Leaf Extract of Cyclea peltate
Fernando, MJJH; Ilangamge, SC; Wimalan, A; Halahakoon, HMAJ; Nelumdeniya, NRM (2022)Cyclea peltata (Kahipiththan in Sinhala) (C. peltata) is a climbing shrub that belongs to the family Menispermaceae. When the leaf extract is mixed with water, it forms an edible gel that is consumed to treat gastrointestinal ... -
An In-Vitro Evaluation of Photoprotective Potential of Leaf Extracts of Atalantia Ceylanica, Hibiscus Furcatus and Formulated Herbal Sunscreen Gel
Bandara, AAEK; Janaki, TGC; Halahakoon, HMAJ; Kankanamge, SU (2022)Higher exposure to solar radiation may cause skin diseases due to the harmful effects of sunburn. Sunscreen is one of best methods to prevent solar-induced skin cancers and sunburns. Sunscreens consist of natural ... -
Is Discrete Incremental Meta Docking (DIMD) the Key to Success in Molecular Docking-Based Drug Discovery? A Comparison of the Results of the Novel Vinca Derivative VADRPA01
Halahakoon, HMAJ (2024-09-26)Determining the crystal structure of vinca-site inhibitors in complex with the tubulin heterodimer is crucial for understanding binding modes and guiding the design of novel microtubule inhibitors targeting the ... -
The Study of An Anti-Diabetic Activity Using Syzygium Cumini, Costus Speciosus, and Melastoma malabathricum Plant Extracts Compared to Standard Acarbose
Perera, BSS; Pramuditha, PVCI; Halahakoon, HMAJ; Sabalingam, S (2024-09-26)